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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF4
All Species:
23.94
Human Site:
S288
Identified Species:
35.11
UniProt:
O43172
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43172
NP_004688.2
522
58449
S288
F
H
P
K
S
T
V
S
L
D
P
K
D
V
N
Chimpanzee
Pan troglodytes
XP_520198
559
62217
S325
F
H
P
K
S
T
V
S
L
D
P
K
D
V
N
Rhesus Macaque
Macaca mulatta
XP_001102859
521
58408
S287
F
H
P
K
S
T
V
S
L
D
Q
K
D
V
N
Dog
Lupus familis
XP_532038
521
58332
S287
F
H
P
K
S
T
V
S
L
D
Q
K
D
V
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9DAW6
521
58352
S287
F
H
P
K
S
T
V
S
L
D
Q
K
D
V
N
Rat
Rattus norvegicus
Q5BK30
415
45841
N186
E
I
V
C
L
S
F
N
P
Q
S
T
V
V
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518220
390
43930
D161
T
V
S
L
D
K
K
D
V
N
L
A
S
C
A
Chicken
Gallus gallus
Q5ZMA2
505
55116
V272
S
K
K
V
T
S
V
V
F
H
P
S
Q
D
L
Frog
Xenopus laevis
Q5FWQ6
415
45899
N186
E
I
V
C
L
V
F
N
P
Q
S
T
L
I
A
Zebra Danio
Brachydanio rerio
Q1LV15
415
45916
N186
E
I
V
C
L
A
F
N
P
Q
S
T
L
V
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7KNS3
411
46441
Q181
I
K
L
W
D
F
Q
Q
S
Y
E
C
I
K
T
Honey Bee
Apis mellifera
XP_393186
525
59172
T281
F
H
P
K
A
T
I
T
E
E
V
V
G
E
R
Nematode Worm
Caenorhab. elegans
Q10051
492
53189
N263
A
V
V
L
H
P
D
N
I
T
A
I
S
A
S
Sea Urchin
Strong. purpuratus
XP_795434
502
56264
S268
F
H
P
Q
A
T
L
S
L
S
P
N
A
C
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O22212
554
61823
V304
H
K
E
R
A
T
D
V
V
F
S
P
V
D
D
Baker's Yeast
Sacchar. cerevisiae
P20053
465
52424
S236
D
S
N
N
Q
M
I
S
C
A
E
D
G
L
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.8
99
99.2
N.A.
98.8
25.4
N.A.
71.2
21
24.1
24.3
N.A.
22.2
58.2
22
62
Protein Similarity:
100
93.1
99.2
99.6
N.A.
99.4
40.6
N.A.
73.3
41.3
41.3
41.5
N.A.
39.6
72.9
40.6
77
P-Site Identity:
100
100
93.3
93.3
N.A.
93.3
6.6
N.A.
0
13.3
0
6.6
N.A.
0
33.3
0
46.6
P-Site Similarity:
100
100
93.3
93.3
N.A.
93.3
20
N.A.
13.3
26.6
13.3
13.3
N.A.
0
60
20
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
40
31.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.7
51.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
19
7
0
0
0
7
7
7
7
7
25
% A
% Cys:
0
0
0
19
0
0
0
0
7
0
0
7
0
13
7
% C
% Asp:
7
0
0
0
13
0
13
7
0
32
0
7
32
13
7
% D
% Glu:
19
0
7
0
0
0
0
0
7
7
13
0
0
7
0
% E
% Phe:
44
0
0
0
0
7
19
0
7
7
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
13
0
0
% G
% His:
7
44
0
0
7
0
0
0
0
7
0
0
0
0
0
% H
% Ile:
7
19
0
0
0
0
13
0
7
0
0
7
7
7
7
% I
% Lys:
0
19
7
38
0
7
7
0
0
0
0
32
0
7
0
% K
% Leu:
0
0
7
13
19
0
7
0
38
0
7
0
13
7
7
% L
% Met:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
7
0
0
0
25
0
7
0
7
0
0
32
% N
% Pro:
0
0
44
0
0
7
0
0
19
0
25
7
0
0
0
% P
% Gln:
0
0
0
7
7
0
7
7
0
19
19
0
7
0
0
% Q
% Arg:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
7
% R
% Ser:
7
7
7
0
32
13
0
44
7
7
25
7
13
0
7
% S
% Thr:
7
0
0
0
7
50
0
7
0
7
0
19
0
0
7
% T
% Val:
0
13
25
7
0
7
38
13
13
0
7
7
13
44
0
% V
% Trp:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _